20263 publications

• Determinants of Liver Steatosis Progression in Chinese Children: A Prospective Cohort Study.

  Yueju Wang^#, Cai Tang^#, Peiye Yang^#, Xiaowei Zheng, Lihong Zhu, Haoyang Zhang, Le Zhang^*, Qingqing Zheng^*.

  Diabetes, Metabolic Syndrome and Obesity · 2026

• Comparative performance of multiple novel obesity indices for MAFLD screening in Chinese children: the body roundness index as a practical predictor.

  Minhao Fan^#, Cai Tang^#, Shibo Lin^#, Jiahui Zhang, Xiaowei Zheng, Lihong Zhu, Le Zhang^*, Xiaomin Zhu^*, Yun Li^*.

  Frontiers in Medicine · 2026

• Impact of Volatile Organic Compounds on Liver Function in Adolescents: Mediation and Preventive Insights from NHANES.

  Xiaodie Yao^#, Congwei You^#, Min Zhou^#, Huan Zhou, Cai Tang, Haoyang Zhang, Xiaolei Wang^*, Weilai Jin^*, Le Zhang^*.

  Current Pharmaceutical Design · 2026

202512 publications

• Exclusive Breastfeeding Drives AMPK-Dependent Thermogenic Memory in BAT and Promotes Long-Term Metabolic Benefits in Offspring.

  Ningxi Wu^#, Anwen Yin^#, Xiang Yu^#, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo^*, Le Zhang^*, Yun Li^*.

  Advanced Science · 2025

• Computational Toxicology to Elucidate PFASs Causing Fetal Growth Restriction via Binding to and Degrading IGF1 Protein.

  Shimin Tao^#, Yahui Zhou^#, Xuhui Zhang, Jiamei Ji, Yan Wang^*, Le Zhang^*.

  Environmental Science & Technology · 2025

• The Glutamine Metabolic Switch Influences the Response of Neonatal Intestinal Macrophages to Breast Milk.

  Xu Han^#, Yutong Hou^#, Taoying Chen^#, Zhenyu Jia^#, Fuqiang Yuan, Mingxin Wang, Yinglin Su, Ru Yan, Xiaolei Wang, Weilai Jin, Yahui Zhou^*, Yun Li^*, Le Zhang^*.

  Cellular and Molecular Gastroenterology and Hepatology · 2025

• Wearable device–measured physical activity and risk of MAFLD in adolescents.

  Ruli Wang^#, Congwei You^#, Zhijuan Dong^#, Qingqing Zheng, Xiaowei Zheng, Liangbin Zhou, Xiaolei Wang^*, Le Zhang^*, Haoyang Zhang^*.

  American Journal of Preventive Cardiology · 2025

• Association of exposure to phenols, pesticides, and phthalates with hepatic steatosis and MASLD in adolescents: the potential role of inflammation and lifestyle factors.

  Xiaodie Yao^#, Cai Tang^#, Yu Li^#, Congwei You, Haoyang Zhang, Xiaohong Gu^*, Kerong Liu^*, Le Zhang^*.

  Metab Target Organ Damage · 2025

• Resilience of Pediatric Healthcare Services in an Urban Hospital in China During the COVID-19 Pandemic in Late 2022.

  Hongwei Chen^#, Mengyuan Hu^#, Huiyao Chen, Juan Yang, Fan Yang, Yahui Li, Zhenzhen Pan, Qiming Pan, Huili Ju, Lihong Zhu, Le Zhang^*, Haoyang Zhang^*.

  BMJ Paediatrics Open · 2025 Letter

• Impact of segmental body composition on metabolic dysfunction-associated fatty liver disease in Chinese children

  Mengyuan Hu^#, Danqin Sun^#, Fan Yang^#, Xiaowei Zheng, Ningxi Wu, Haoyang Zhang, Xiaodie Yao^*, Jiahui Zhang^*, Le Zhang^*.

  Frontiers in Endocrinology · 2025

• The association between working hours and working type with non-alcoholic fatty liver disease: results from the NHANES 1999-2014.

  Ruli Wang^#, Ningxi Wu^#, Huan Qu^#, Xiaowei Zheng, Haoyang Zhang, Lihong Zhu, Xiaolei Wang^*, Xiaodie Yao^*, Le Zhang^*.

  Frontiers in Endocrinology · 2025

• Exposure to Chinese famine in early life and the risk of multimorbidity in adulthood.

  Jiahui Zhang, Le Zhang^*, Wenyan Wu^*, Xiaowei Zheng^*.

  BMC Public Health · 2025

• Potential alternative and novel biomarkers for paediatric MAFLD: exploratory evidence from a Chinese cohort.

  Fan Yang, Mengyuan Hu, Lulian Xu, Xiaowei Zheng, Lihong Zhu, Le Zhang, Haoyang Zhang.

  BMC Gastroenterology · 2025

• Mitochondrial Dysfunction as a Pathophysiological Bridge between Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Kidney Disease.

  Congwei You^#, Anwen Yin^#, Jia Xia, Le Zhang^*, Xiaolei Wang^*, Yutong Hou^*.

  BIOCELL · 2025 Review

• Mitochondrial Oxidative Stress-Associated Mechanisms in the Development of Metabolic Dysfunction-Associated Steatotic Liver Disease.

  Juan Yang^#, Jiahui Zhang^#, Le Zhang^*, Zhenshan Yang^*.

  BIOCELL · 2025 Review

20249 publications

• An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease.

  Le Zhang, Mortada El-Shabrawi, Louise A Baur, Christopher D Byrne, Giovanni Targher, Mohit Kehar, Gilda Porta, Way Seah Lee, Sander Lefere, Serap Turan, Anna Alisi, Ram Weiss, Maria Felicia Faienza, Ambika Ashraf, Shikha S Sundaram, Anshu Srivastava, Ruth De Bruyne, Yunkoo Kang, Flora Bacopoulou, Yong-Hai Zhou, Andy Darma, Monica Lupsor-Platon, Masahide Hamaguchi, Anoop Misra, Nahum Méndez-Sánchez, Nicholas Beng Hui Ng, Claude Marcus, Amanda E Staiano, Nadia Waheed, Saleh A Alqahtani, Cosimo Giannini, Ponsiano Ocama, Mindie H Nguyen, Maria Teresa Arias-Loste, Mohamed Rabea Ahmed, Giada Sebastiani, Yong Poovorawan, Mamun Al Mahtab, Juan M Pericàs, Themis Reverbel da Silveira, Peter Hegyi, Amer Azaz, Hasan M Isa, Chatmanee Lertudomphonwanit, Mona Issa Farrag, Ahmed Abd Alwahab Nugud, Hong-Wei Du, Ke-Min Qi, Nezha Mouane, Xin-Ran Cheng, Tawfiq Al Lawati, Eleonora D T Fagundes, Hasmik Ghazinyan, Adamos Hadjipanayis, Jian-Gao Fan, Nicoleta Gimiga, Naglaa M Kamal, Gabriela Ștefănescu, Li Hong, Smaranda Diaconescu, Ming Li, Jacob George^*, Ming-Hua Zheng^*.

  Med · 2024

• Intestinal stem cell-derived extracellular vesicles ameliorate necrotizing enterocolitis injury.

  Le Zhang^#, Jiahong Li^#, Qiwen Wan^#, Chaozhi Bu, Weilai Jin^*, Fuqiang Yuan^*, Wenhao Zhou^*.

  Mol Cell Probes · 2024

• Silencing miR-155-5p expression improves intestinal damage through inhibiting inflammation and ferroptosis in necrotizing enterocolitis.

  Le Zhang^#*, Weilai Jin^#, Mengyuan Hu^#, Yinglin Su, Yiting Zhang, Fuqiang Yuan, Yuanyuan Fang, Zhengying Li, Yawen Li^*, Chaozhi Bu^*, Wenhao Zhou^*.

  Heliyon · 2024

• The Human Milk-derived Peptide Drives Rapid Regulation of Macrophage Inflammation Responses in the Neonatal Intestine

  Fuqiang Yuan^#, Xu Han^#, Masha Huang^#, Yinglin Su^#, Yiting Zhang, Mengyuan Hu, Xiang Yu, Weilai Jin^#*, Yun Li^#*, Le Zhang^#*.

  Cell Mol Gastroenterol Hepatol · 2024

• Cell‐permeable JNK‐inhibitory peptide regulates intestinal barrier function and inflammation to ameliorate necrotizing enterocolitis

  Chaozhi Bu^#, Mengyuan Hu^#, Yinglin Su^#, Fuqiang Yuan, Yiting Zhang, Jing Xia^*, Zhenyu Jia^*, Le Zhang^*.

  J Cell Mol Med · 2024

• Hyperoxia exposure induces ferroptosis and apoptosis by downregulating PLAGL2 and repressing HIF-1α/VEGF signaling pathway in newborn alveolar typeII epithelial cell.

  Yuting Zhu^#, Hongmei Hou^#, Yawen Li^#, Yanyu Zhang, Yuanyuan Fang, Si Chen, Le Zhang^*, Weilai Jin^*, Yahui Zhou^*.

  Redox Report · 2024

• Behenic acid alleviates inflammation and insulin resistance in gestational diabetes mellitus by regulating TLR4/NF-κB signaling pathway.

  Kerong Liu^#, Ying Gu^#, Xingnan Pan^#, Sha Chen, Jie Cheng^*, Le Zhang^*, Minkai Cao^*.

  iScience · 2024

• Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production

  Li-Long Pan^#*, Yudong Sun^#, Xiaoliang Dong^#, Zhengnan Ren, Binbin Li, Ping Yang, Le Zhang^*, Jia Sun^*.

  Gut Microbes · 2024

• Protocol for a Longitudinal Cohort Study to Understand Characteristics and Risk Factors Underlying Vibration-Controlled Transient Elastography-Diagnosed Metabolic Dysfunction-Associated Fatty Liver Disease Children.

  Fan Yang^#, Mengyuan Hu^#, Haoyang Zhang, Xiaowei Zheng, Limei Chen, Lihong Zhu^*, Le Zhang^*.

  Diabetes Metab Syndr Obes · 2024 Study protocol

Before 202426 publications

• Reversal of H2O2-induced cell death by knockdown of HOTAIR in HTR-8/SVneo cells by mediation of miR-106b-5p/ACSL4 axis.

  Minkai Cao^#, Weilai Jin^#, Ying Li^#, Mingxin Wang, Faguang Wan, Yongwei Ren, Ying Gu^*, Jinqi Ma^*, Le Zhang^*.

  Funct Integr Genomics · 2023

• Dysregulation of gut health in zebrafish by differentially charged nanoplastic exposure: an integrated analysis of histopathology, immunology, and microbial informatics.

  Zhimin Xu, Yuxue Zhang, Zhihao Xu, Yuming Zhong, Lei Wang, Chunguang Liu, Ailing Chen, Shanyu Jiang, Weimin Sun, Guohui Yu, Yanling Li, Chengzhang Li, Yifan Wang, Renqiang Yu^*, Le Zhang^*.

  Environmental Science: Nano · 2023

• Highly Valuable Fish Oil: Formation Process, Enrichment, Subsequent Utilization, and Storage of Eicosapentaenoic Acid Ethyl Esters

  Mengyuan Yi, Yue You, Yiren Zhang, Gangcheng Wu^*, Emad Karrar, Le Zhang^*, Hui Zhang, Qingzhe Jin, Xingguo Wang.

  Molecules · 2023 Review

• Lipid Profiles of Human Milk and Infant Formulas: A Comparative Lipidomics Study.

  Danjie Wu, Le Zhang, Yan Zhang, Jiachen Shi, Chin Ping Tan, Zhaojun Zheng, Yuanfa Liu.

  Foods · 2023

• Comparative Lipidomic Analysis Reveals the Lactational Changes in the Lipid Profiles of Chinese Human Milk.

  Danjie Wu^#, Le Zhang^#, Chin Ping Tan, Zhaojun Zheng^*, Yuanfa Liu^*.

  Journal of Agricultural and Food Chemistry · 2023

• A 3D culture system improves the yield of MSCs-derived extracellular vesicles and enhances their therapeutic efficacy for heart repair.

  Ling Sun^#, Yuan Ji^#, Boyu Chi^#, Tingting Xiao, Chenkai Li, Xuejiao Yan, Xu Xiong, Lipeng Mao, Dabei Cai, Ailin Zou, Yu Wang, Le Zhang^*, Liming Tang^*, Qingjie Wang^*.

  Biomedicine & Pharmacotherapy · 2023

• The Protective Effect of Broccoli Seed Extract against Lipopolysaccharide-Induced Acute Liver Injury via Gut Microbiota Modulation and Sulforaphane Production in Mice.

  Bingyong Mao, Baojing Ren, Jiaying Wu, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Le Zhang^*, Wei Chen, Shumao Cui^*.

  Foods · 2023

• Tat-P combined with GAPR1 releases Beclin1 to promote autophagy and improve Bronchopulmonary dysplasia model

  Yahui Zhou^#*, Yuting Zhu^#, Weilai Jin^#, Ru Yan, Yuanyuan Fang, Fan Zhang, Tonghui Tang, Si Chen, Jing Chen, Fan Zhang, Zhangbin Yu^*, Le Zhang^*, Zhiwei Yu^*.

  iScience · 2023

• Symptom profiles and vaccination status for COVID-19 after the adjustment of the dynamic zero-COVID policy in China: an observational study.

  Haoyang Zhang^#, Zhenxing Lu^#, Fan Yang, Hongwei Chen, Le Zhang^*, Huiying Zhao^*, Yongkun Chen^*.

  J Med Virol · 2023

• Skeletal muscle HSF1 prevents insulin resistance by improving glucose utilization.

  Yun Li^#, Shibo Lin^#, Xu Xu, Weilai Jin, Yinglin Su, Fuqiang Yuan, Yiting Zhang, Zhengying Li, Yahui Zhou^*, Lihong Zhu^*, Le Zhang^*.

  FASEB J · 2022

• Differential circular RNA expression profiles in umbilical cord blood exosomes from preeclampsia patients.

  Minkai Cao^#, Juan Wen^#, Chaozhi Bu, Chunyan Li, Yu Lin, Hong Zhang, Yanfang Gu, Zhonghua Shi, Yan Zhang^*, Wei Long^*, Le Zhang^*.

  BMC Pregnancy Childbirth · 2021

• CRAMP-encoding Lactobacillus plantarum FCQHC24 attenuates experimental colitis in mice.

  Li-Long Pan^#, Ming Zhang^#, Zhengying Li^#, Binbin Li, Xiaohua Pan, Xiaopei Chen, Bo Yang, Hao Zhang, Wei Chen, Le Zhang^*, Jia Sun^*.

  Food Bioscience · 2021

• HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction.

  Qingjie Wang^#, Le Zhang^#, Zhiqin Sun^#, Boyu Chi, Ailin Zou, Lipeng Mao, Xu Xiong, JianGuang Jiang, Ling Sun^*, Wenwu Zhu^*, Yuan Ji^*.

  Materials Today Bio · 2021

• Association of maternal serum 25-hydroxyvitamin D concentrations with risk of pre-eclampsia: a nested case-control study and meta-analysis.

  Yingdi Yuan^#, Wen Tai^#, Pengfei Xu, Ziyi Fu, Xiaolei Wang, Wei Long, Xirong Guo, Chenbo Ji, Le Zhang^*, Yue Zhang^*, Juan Wen^*.

  Journal of Maternal-Fetal & Neonatal Medicine · 2021 Review

• The restoration of Wnt/β-catenin signalling activity by a tuna backbone-derived peptide ameliorates hypoxia-induced cardiomyocyte injury.

  Le Zhang^#, Minkai Cao^#, Zhiwei Yu^#, Siliang Xu^#, Liang Ju, Jun Qian, Tianyu Li, Jianjuan Xu, Wei Qian^*, Jian Zhou^*, Zhengying Li^*.

  American Journal of Translational Research · 2020

• Peptidomics analysis discloses that novel bioactive peptides participate in necrotizing enterocolitis in a rat model.

  Yiwen Liu^#, Changlin Wang^#, Renqiang Yu^#, Jianfeng Fan^#, Weilai Jin, Yuting Zhu, Yingzuo Shi, Yulei Jing, Xiaolei Wang, Zhengying Li^*, Jian Zhou^*, Le Zhang^*.

  BioMed Research International · 2020

• Integrated analysis of a lncRNA–mRNA network reveals a potential mechanism underlying necrotizing enterocolitis.

  Wenjuan Chen^#, Xiangyun Yan^#, Tian Tian^#, Ru Yan, Xingyun Wang, Zhangbin Yu, Yingzheng Li, Le Zhang^*, Shuping Han^*.

  Molecular Medicine Reports · 2020

• Differential mRNA and long noncoding RNA expression profiles in umbilical cord blood exosomes from gestational diabetes mellitus patients.

  Minkai Cao, Le Zhang, Yu Lin, Zhengying Li, Jianjuan Xu, Zhonghua Shi, Zhong Chen, Jinqi Ma, Juan Wen.

  Dna And Cell Biology · 2020

• Circular RNA expression profiles in umbilical cord blood exosomes from normal and gestational diabetes mellitus patients.

  Minkai Cao^#, Le Zhang^#, Yu Lin, Zhengying Li, Jianjuan Xu, Zhonghua Shi, Zhong Chen^*, Jinqi Ma^*, Juan Wen^*.

  Bioscience Reports · 2020

• Genetic susceptibility to gestational diabetes mellitus in a Chinese population.

  Minkai Cao^#, Le Zhang^#, Ting Chen, Aiwu Shi, Kaipeng Xie, Zhengying Li, Jianjuan Xu, Zhong Chen^*, Chenbo Ji^*, Juan Wen^*.

  Frontiers in Endocrinology · 2020

• Regulation of ROS-NF-κB axis by tuna backbone derived peptide ameliorates inflammation in necrotizing enterocolitis.

  Le Zhang, Jianfeng Fan, Jingya He, Wenjuan Chen, Weilai Jin, Yuting Zhu, Haibing Sun, Yawen Li, Yingzuo Shi, Yulei Jing, Xiaolei Wang^*, Shuping Han^*, Zhengying Li^*.

  Journal of Cellular Physiology · 2019

• A genetic variant in LINGO2 contributes to risk of gestational diabetes mellitus in a Chinese Population.

  Tong Su, Qingxia Ren, Yingying Lu, Wen Tai, Yuan Zhu, Zhengying Li, Juan Wen, Lingmin Hu^*, Le Zhang^*, Jiehua Ma^*.

  Journal of Cellular Physiology · 2019

• Genetic variants in AC092159.2 and risk of gestational diabetes mellitus in a Chinese population.

  Deliang Hu, Weijuan Miao, Ting Chen, Kaipeng Xie, Aiwu Shi, Le Zhang^*, Rui Li^*, Juan Wen^*.

  Dna And Cell Biology · 2019

• Identification and Peptidomic Profiling of Exosomes in Preterm Human Milk: Insights Into Necrotizing Enterocolitis Prevention.

  Xingyun Wang, Xiangyun Yan, Le Zhang, Jinyang Cai, Yahui Zhou, Heng Liu, Yin Hu, Wenjuan Chen, Siliang Xu, Peipei Liu, Ting Chen, Jun Zhang, Yan Cao^*, Zhangbin Yu^*, Shuping Han^*.

  Molecular Nutrition & Food Research · 2019

• Peptidomic analysis reveals multiple protection of human breast milk on infants during different stages.

  Yahui Zhou, Le Zhang, Zhangbin Yu, Aiqing Zhang, Weimin Wu, Wenjuan Chen, Xiangyun Yan, Heng Liu, Yin Hu, Chengyao Jiang, Yan Xu, Xingyun Wang^*, Shuping Han^*.

  Journal of Cellular Physiology · 2019

• Peptidome analysis of lung tissues from a hyperoxia-induced bronchopulmonary dysplasia mouse model: Insights into the pathophysiological process of bronchopulmonary dysplasia.

  Jing Yin^#, Xingyun Wang^#, Le Zhang^#, Xing Wang, Heng Liu, Yin Hu, Xiangyun Yan, Yongfeng Tang, Juan Wang, Zhengyin Li, Zhangbin Yu, Yan Cao^*, Shuping Han^*.

  Journal of Cellular Physiology · 2018